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  • 科室介绍

  • 图文组件
  • 图文组件

Overview
Department of Rheumatology and Immunology, Peking University People's Hospital, the Center of Clinical Immunology, Peking University, is one of the earliest and largest rheumatology centers in China. As a top National Key Center specialized in Rheumatology, the center has been titled as a National Center of Excellence in Rheumatology (certified in 2013), a National Key Laboratory in Clinical Immunology of the Ministry of Education of China (certified in 2005), Innovation team of the Ministry of Education of China (certified in 2011), Beijing Key Laboratory (certified in 2012), and the only International Cooperation Base in Rheumatic Diseases in Beijing (certified in 2015).

 

There are over 120 clinical and research faculties in this center, including 24 Professors and Associate Professors, 11 Attending physicians and residents, 25 nurses, 11 laboratory staff and nearly 40 PhD, Master and Post-doctoral researchers. Among them, there are 10 PhD supervisors, 12 cosupervisors or postgraduate supervisors. 23 persons have studied abroad, 42 have published papers in English in international journals, 31 have been the project leaders of one or more national/Beijing Science and Technology Projects, 5 have been the leaders of national key or major projects.

 

The academic participations of the staff include Past-President of International Leagues Associations of Rheumatology (ILAR), Past-President of Asia Pacific League of Associations for Rheumatology (APLAR), Past-President of Chinese Rheumatology Association, President of Clinical Immunology Association of China, President of Chinese association of women in Rheumatology and Immunology, member of WHO-ICC, member of Chinese Rheumatology Association, member of Chinese Rheumatology Association, etc. The staff also serve as Associate Editor of Clinical Rheumatology, Int J Rheumatic Diseases, Semin Arthritis Rheu, Journal of Gene Medicine and Immunology, Chief Editor of Chinese Journal of Rheumatology, Journal of Clinical Immunology and Rheumatology, editorial board member of Nature Reviews Rheumatology, Lancet Rheumatology, Rheumatology, Current Opinion in Rheumatology, Ann Rheum Dis, Clin Exp Rheumatology, Chinese Journal of Internal Medicine and National Medical Journal of China, reviewers of Lupus, J Rheumatology and over 10 other domestic and international journals.

 

A number of academic honors have been achieved, including "973" Chief Scientist, CMB Distinguished Professor, Winners of National Outstanding Youth Fund, Yang Wu Prize winner, the Ministry of Education Cross-Century Talents, China Medical Science and Technology Prize, China Medical Science and Technology Award, University Scientific Research and Technological Progress Award, Beijing Science Nova, National Tech-Distinguished Talent, National Ten Thousand Talents Plan, Young Changjiang Scholar etc.

The center has published over 830 papers as first or corresponding authors in Nature Medicine, Lancet Rheumatology, Immunity, Science and JAMA Network Open, Cell Host Microbe, Immunity, Annals of Internal Medicine, Annals of the Rheumatic Diseases, Arthritis Rheum, Autoimmunity, etc, among which over 380 are SCI papers. The center edited, translated or participated in the editing of over 30 books in rheumatology including Rheumatology, Kelley's Textbook of Rheumatology, Sjögren’s syndrome, etc.

 

The center focuses on rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome, and has researched and developed more than 20 new specific markers and immune techniques in diagnosis, such as antibodies to the citrullinated HPVP, antibodies to citrullinated fibrinogen peptide, anti-mDNA, anti-nucleosome, anti- M3 receptor and anti-α-fodrin antibodies. Meanwhile, over 10 novel immune-based therapies have been used such as ld-IL-2 for SLE/RA/DM, T cell vaccination for SLE and RA.

 

Publications

  1. He J, Chen J, Miao M, Zhang R, Cheng G, Wang Y, Feng R, Huang B, Luan H, Jia Y, Jin Y, Zhang X, Shao M, Wang Y, Zhang X, Li J, Zhao X, Wang H, Liu T, Xiao X, Zhang X, Su Y, Mu R, Ye H, Li R, Liu X, Liu Y, Li C, Liu H, Hu F, Guo J, Liu W, Zhang WB, Jacob A, Ambrus JL Jr, Ding C, Yu D, Sun X, Li Z. Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(11):e2241451. (IF:13.353)
  2. Zhang X, Miao M, Zhang R, Liu X, Zhao X, Shao M, Liu T, Jin Y, Chen J, Liu H, Zhang X, Li Y, Zhou Y, Yang Y, Li R, Yao H, Liu Y, Li C, Li Y, Ren L, Su Y, Sun X, He J, Li Z. Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial. Signal Transduct Target Ther. 2022 Mar 7;7(1):67.(IF:38.104)
  3. Xiaolin Sun, Haotian Zhou, Xiaozhen Zhao, Ruijun Zhang, Miao Miao, Wenwen Pei, Zijun Li, Yimin Li, Jing He, and Zhanguo Li. Low-dose IL-2 supplementation mitigates glucocorticoid induced Treg impairment and promotes improvement of SLE. Signal Transduct Target Ther.(已接收, IF:38.104)
  4. Guo J, Zhang T, Li X, Cao H, Li Z. Response to: 'Questions on 'Sequencing of the MHC region defines HLA-DQA1 as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population' by Guo et al' by Regueiro and Gonzalez. Ann Rheum Dis. 2022 Mar;81(3):e39. (IF:27.973)
  5. Li J, Jin J, Li S, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J, Wang J, Li Z. Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Adv Sci. 2022 Oct;9(30):e2202706. (IF:17.521)
  6. He J, Chu Y, Li J, Meng Q, Liu Y, Jin J, Wang Y, Wang J, Huang B, Shi L, Shi X, Tian J, Zhufeng Y, Feng R, Xiao W, Gan Y, Guo J, Shao C, Su Y, Hu F, Sun X, Yu J, Kang Y, Li Z. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Sci Adv. 2022 Feb 11;8(6):eabm1511. (IF:14.957)
  7. Li Z, He J, Miao M. Low-dose interleukin-2 therapy in autoimmune and inflammatory diseases: facts and hopes. Sci Bull. (IF:11.78,已接收)
  8. Xing Y, Li B, He J, Hua H. Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren's Syndrome by Targeting PRDM1 and Suppressing Plasma Cells. Front Immunol. 2022 Apr 4;13:871096. (IF:8.786)
  9. Jin J, Xu X, Hou L, Hou Y, Li J, Liang M, Li C. Thrombocytopenia in the first trimester predicts adverse pregnancy outcomes in obstetric antiphospholipid syndrome. Front Immunol. 2022 Aug 18;13:971005. (IF:8.786)
  10. Song X, Fan Y, Jia Y, Li G, Liu M, Xu Y, Zhang J, Li C. A novel aGAPSS-based nomogram for the prediction of ischemic stroke in patients with antiphospholipid syndrome. Front Immunol. 2022 Jul 29;13:930087. (IF:8.786)
  11. Liu X, Zhu L, Liu H, Cai Q, Yun Z, Sun F, Jia Y, Guo J, Li C. Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added. Front Immunol. 2022 Oct 26;13:972012. (IF:8.786)
  12. Yuzhou Gan, Xue Zhong, Yawei Zhao, Gongming Li, Hua Ye and Chun Li. Low Dose Versus Standard Dose Rituximab For The Treatment of Antiphospholipid Syndrome: A Pilot Study From a Tertiary Medical Center. Front Immunol, 2022. (IF:8.786)
  13. Han P, Hou C, Zheng X, Cao L, Shi X, Zhang X, Ye H, Pan H, Liu L, Li T, Hu F, Li Z. Serum Antigenome Profiling Reveals Diagnostic Models for Rheumatoid Arthritis. Front Immunol. 2022;13:884462. (IF:8.786)
  14. Liu X, Zhu L, Liu H, Cai Q, Yun Z, Sun F, Jia Y, Guo J, Li C. Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added. Front Immunol. 2022 Oct 26;13:972012. (IF:8.786)
  15. Zhou X, Wang Y, Huang B, Feng R, Zhou X, Li C, Zhang X, Shao M, Gan Y, Jin Y, An Y, Xiao X, Wang S, Liu Q, Cheng G, Zhu F, Zhang K, Wang N, Xing X, Li R, Li Y, Liu Y, Lu D, Sun X, Li Z, Liu Y, He J. Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three-dose immunization regimen of CoronaVac. Immunology. 2022 Sep 3.( IF:7.215)
  16. Liu H, Li C, Shi H, Guo Y, Tang Y, Chen C, Zhao Z, Hoy CK, Yalavarthi S, Figueroa-Parra G, Duarte-Garcia A, Zuo Y, Li Z, Knight JS, Guo J. Soluble LILRA3 is aberrantly expressed in antiphospholipid syndrome (APS) and is a potential marker of thrombotic APS. Rheumatology (Oxford). 2022 Mar 24:keac192.( IF:7.046)
  17. Zhang K, An Y, Zhao P, Huang B, Wang Y, Zhou X, Cheng G, Xing X, Wang N, Feng R, Yu S, Li M, He J, Li Z. Predictors and prognostic stratification for lupus low disease activity state: Results from a prospective clinical trial. Rheumatology (Oxford). 2022 Jul 27:keac419. ( IF:7.046)
  18. Zhong H, Liu T, Liu Y, Zhang X, Zhou Y, Su Y. Efficacy and safety of tocilizumab in Behçet's syndrome with refractory arterial lesions: a single-centre observational cohort study in China. Rheumatology (Oxford). 2022 Jul 6;61(7):2923-2930. ( IF:7.046)
  19. Xie Y, Jia Y, Li Z, Hu F. Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy. Expert Opin Ther Targets. 2022 May;26(5):461-477.( IF:6.797)
  20. Guo Q, He Y, Liu X, Gao X, Xu J, Li X, Sun Y, Xiang Y, Li R, Li Z. Features of hyperintense white matter lesions and clinical relevance in systemic lupus erythematosus. Chin Med J. 2022 Apr 20;135(8):962-970. (IF:6.133)
  21. Li C, Zuo Y, Zhang S, Makris UE, Karp DR, Li Z. Additional risk factors associated with thrombosis and pregnancy morbidity in a unique cohort of antiphospholipid antibody-positive patients. Chin Med J 2022 Mar 20;135(6):658-664. (IF:6.133)
  22. Gao X, He J, Sun X, Li F. Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus. iScience. 2022 Aug 11;25(9):104911. (IF:6.106)
  23. Zhufeng Y, Xu J, Miao M, Wang Y, Li Y, Huang B, Guo Y, Tian J, Sun X, Li J, Lu D, Li Z, Li Y, He J. Modification of Intestinal Microbiota Dysbiosis by Low-Dose Interleukin-2 in Dermatomyositis: A Post Hoc Analysis From a Clinical Trial Study. Front Cell Infect Microbiol. 2022 Mar 14;12:757099. (IF:6.073)
  24. Wu M, Yu S, Chen Y, Meng W, Chen H, He J, Shen J, Lin X. Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity. J Leukoc Biol. 2022 Oct;112(4):875-885. (IF:6.011)
  25. Shi M, Gao W, Jin Y, Zhu J, Liu Y, Wang T, Li C. Antiphospholipid Syndrome-Related Pulmonary Embolism: Clinical Characteristics and Early Recognition. Front Cardiovasc Med. 2022 Jul 11;9:872523. (IF:5.846)
  26. Gan Y, Zhao Y, Li G, Ye H, Zhou Y, Hou C, Wang L, Guo J, Li C. Risk Factors and Outcomes of Acute Myocardial Infarction in a Cohort of Antiphospholipid Syndrome. Front Cardiovasc Med. 2022 Jul 5;9:871011. (IF:5.846)
  27. Xie Y, Jiang X, Wang P, Zheng X, Song J, Bai M, Tang Y, Fang X, Jia Y, Li Z, Hu F. SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis. Clin Exp Immunol. 2022 May 12;207(3):297-306. (IF:5.732)
  28. Zheng L, Xu L, Hu F, Xue J, Bai M, Yao R, Zhu H, Zhong H, Su Y. Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis. Clin Exp Immunol. 2022 Sep 29;209(3):270-279. (IF:5.732)
  29. Feng R, Zhao J, Sun F, Miao M, Sun X, He J, Li Z. Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjögren's syndrome. Ann Med. 2022 Dec;54(1):472-483. (IF:5.348)
  30. Wang Y, Feng R, Cheng G, Huang B, Tian J, Gan Y, Jin Y, Miao M, Zhang X, Sun X, He J, Li Z. Low Dose Interleukin-2 Ameliorates Sjögren's Syndrome in a Murine Model. Front Med (Lausanne). 2022 May 19;9:887354.(IF:5.058)
  31. Shi Q, Ning X, Li H, Ma X, Wang K, Bian W, Zhang Y, Xia J, Zheng X, Liu Y, Li Z. Characteristics of IgG4-related disease complicated with allergic rhinitis or chronic rhinosinusitis: a large cross-sectional cohort study. Sci Rep. 2022 Jul 14;12(1):12039. (IF:4.996)
  32. Cai W, Li R, He J, Shao M, Li Z. A Rare Case of Neurosarcoidosis Overlapped with Sjogren's Syndrome. J Clin Med. 2022 Sep 27;11(19):5709. (IF:4.964)
  33. Li Y, Li Y, Wang Y, Shi L, Lin F, Zhang Z, Zhang J, Xu F, Sun X. Nomogram to predict dermatomyositis prognosis: a population-based study of 457 cases. Clin Exp Rheumatol. 2022 Feb;40(2):247-253. (IF:4.862)
  34. Zhang Y, Bao H, Zhang X, Yang F, Liu Y, Li H, Lu J, Liu Y. Kimura's disease: clinical characteristics, management and outcome of 20 cases from China. Clin Exp Rheumatol. 2022 Mar;40(3):532-538. (IF:4.862)
  35. Miao M, Li Y, Xu D, Zhang R, He J, Sun X, Li Z. Therapeutic responses and predictors of low-dose interleukin-2 in systemic lupus erythematosus. Clin Exp Rheumatol. 2022 May;40(5):867-871. (IF:4.862)
  36. Wang Z, Li J, Zhang X, Zeng Q, Wang Z, Yang F, Bian W, Fu J, Zhang Y, Chi X, Wu Y, Shi Q, An Z, Liu Y. Clinical characteristics of IgG4-related respiratory disease patients: a large Chinese cohort study. Clin Exp Rheumatol. 2022 Sep;40(9):1629-1635. (IF:4.862)
  37. Bai M, Xu L, Zhao Z, Xue J, Zhong H, Liu T, Sun F, Yao H, Hu F, Su Y. Decreased perforin-producing B cells correlate with systemic lupus erythematosus. Clin Exp Rheumatol. 2022 Aug 31. (IF:4.862)
  38. Guo Y, Li X, Li R, Li Y, Wang Z, Liu H, Cao S, Li R, Zhao Y, Wang Q, Sun X. Utility of autoantibody against an UCH-L1 epitope as a serum diagnostic marker for neuropsychiatric systemic lupus erythematosus. Clin Exp Rheumatol. 2022 Nov;40(11):2078-2087. (IF:4.862)
  39. Shao M, Miao M, Zhang X, Zhang X, An Y, Guo H, Lei L, Zhao Q, Ding Y, Lin J, Wu R, Yu F, Li Y, Miao H, Zhang L, Du Y, Jiao R, Pang L, Long L, Yao X, Shi X, Wang F, Cui L, Zhang L, Liu S, Lu F, Luo K, Zhao S, Wang Y, Wu X, Wang Q, Liu H, Song S, Zhou X, Zhang X, Shi S, Zhu H, Chen Y, Yu H, Wu J, Yu R, Fan W, Liu S, Xu J, Chen Z, Shi L, He J, Zhang X, Li Z, Li R. Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study. Lupus Sci Med. 2022 Nov;9(1):e000779. (IF:4.687)
  40. Liu Y, Liu S, Liu L, Gong X, Liu J, Sun L, Liu X, Wu L, Chen L, Wang L, Luo L, Lin J, Tie N, Jiang Z, Wu J, Lu F, Sun H, Li X, Yang N, Chai K, Wei H, Da Z, Zhao C, Dai L, Wang Y, Shi G, Zhang Z, Song H, Guo Q, Liu YC, Li Z. Fine Comparison of the Efficacy and Safety Between GB242 and Infliximab in Patients with Rheumatoid Arthritis: A Phase III Study. Rheumatol Ther. 2022 Feb;9(1):175-189.( IF:4.081)
  41. Bian W, Li Y, Sun F, Sun X, Li R, Xia C, Fu J, Zhang Y, Chen S, Liu Y. Immune phenotype changes in IgG4-related disease: CD161 + Treg and Foxp3 +  Clin Rheumatol. 2022 Dec 25. (IF:3.65)
  42. Gao C, Zhong H, Chen L, Wang L, Yao H, Huang X, Jia Y, Li C, Liu T. Clinical and psychological assessment of patients with rheumatoid arthritis and fibromyalgia: a real-world study. Clin Rheumatol. 2022 Apr;41(4):1235-1240. (IF:3.65)
  43. Zhou X, Li Q, Li Y, Fu J, Sun F, Li Y, Wang Y, Jia Y, Zhang Y, Jia R, Hu F, Li Y. Diminished natural killer T-like cells correlates with aggravated primary Sjögren's syndrome. Clin Rheumatol. 2022 Apr;41(4):1163-1168. (IF:3.65)
  44. Luo L, Li X, Yan R, Zhang H, Li C. Risk factors for adverse pregnancy outcomes in women with rheumatoid arthritis and follow-up of their offspring. Clin Rheumatol. 2022 Oct;41(10):3135-3141. (IF:3.65)
  45. Cao L, Zheng X, Han P, Ren L, Wang J, Hu F, Li Z. Raman spectroscopy as a promising diagnostic method for Rheumatoid Arthritis. Analytical Methods. (IF:3.6,已接收)
  46. Liu Y, Wang Z, Ren L, Zeng Q, Wang Z, Bian W, Zhang Y, Fu J, Chen D, Yu G, Zhang S, Li Z. Sonographic findings of immunoglobulin G4-related sialadenitis and differences from Sjögren's syndrome. Scand J Rheumatol. 2022 Mar;51(2):128-134. (IF:3.057)
  47. Wei Y, Zhao J, Ming J, Zhang X, Chen Y. Patient Preference for Self-Injection Devices in Rheumatoid Arthritis: A Discrete Choice Experiment in China. Patient Prefer Adherence. 2022 Aug 31;16:2387-2398. (IF:2.314)
  48. Zhou W, Liu T, Xiao X, He J. Refractory Behçet's disease treated with low-dose interleukin-2: A case report. Medicine (Baltimore). 2022 Oct 21;101(42):e31173. (IF:1.817)
  49. Yan R, Jin YB, Li XR, Luo L, Liu XM, He J. Clinical characteristics of rheumatic disease-associated hypophysitis: A case series and review of literature. Medicine. 2022 Oct 28;101(43):e31338. (IF:1.552)
  50. Alexander Jacob, Long Shen, Jing He, Kelly Nealon, Jessy J, Alexander Julian L, Ambrus Jr. Effect of lymphotoxin blockage on different stages of Sjogren's syndrome in an animal model. Rheumatol & Autoimmun. 2022;2:76–81.
  51. Zhao X, Chen Y, Wen W, et al. Identification of lipopolysaccharide-binding protein as a novel citrullinated autoantigen in rheumatoid arthritis. Rheumatol & Autoimmun. 2022;2:5-14.
  52. Xing XY, Zhang JX, Zhu FY, Wang YF, Zhou XY, Li YH. Clinical analysis of 5 cases of dermatomyositis complicated with macrophage activation syndrome. Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Dec 18;54(6):1214-1218. Chinese.
  53. Li GM, Jin YB, Gan YZ, Chen C, Jia Y, Li C. Ruxolitinib as an effective treatment for panniculitis associated hemophagocytic syndrome: A report of 2 cases and literature review. Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Dec 18;54(6):1208-1213. Chinese.
  54. Cai WX, Li SC, Liu YM, Liang RY, Li J, Guo JP, Hu FL, Sun XL, Li C, Liu X, Ye H, Deng LZ, Li R, Li ZG. A cross-sectional study on the clinical phenotypes of rheumatoid arthritis. Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Dec 18;54(6):1068-1073.
  55. Mu R, Li C, Li X, Ke Y, Zhao L, Chen L, Wu R, Wu Z, Zuo X, Xie Y, Chen J, Wei W, Liu Y, Li Z, Dai L, Sun L, Liu X, Li Z. Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. Lancet Reg Health West Pac. 2021 Mar 22;10:100128.
  56. Sun X, Li R, Cai Y, Al-Herz A, Lahiri M, Choudhury MR, Hidayat R, Suryana BPP, Kaneko Y, Fujio K, Van Hung N, Pandya S, Pang LK, Katchamart W, Sigdel KR, Paudyal B, Narongroeknawin P, Chevaisrakul P, Sun F, Lu Y, Ho C, Yeap SS, Li Z; APLAR RA SIG group. Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region. Lancet Reg Health West Pac. 2021 Aug 12;15:100240.
  57. Deng J, Chen Q, Chen Z, Liang K, Gao X, Wang X, Makota FV, Ong HS, Wan Y, Luo K, Gong D, Yu X, Camuglia S, Zeng Q, Zhou T, Xue F, He J, Wei Y, Xiao F, Ma J, Hill DL, Pierson W, Nguyen THO, Zhou H, Wang Y, Shen W, Sun L, Li Z, Xia Q, Qian K, Ye L, Rockman S, Linterman MA, Kedzierska K, Shen N, Lu L, Yu D. The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses. Nat Commun. 2021 May 24;12(1):3073.
  58. Zhang Y, Li Y, Zhang J, Chen X, Zhang R, Sun G, Jiang B, Fan K, Li Z, Yan X. Nanocage-Based Capture-Detection System for the Clinical Diagnosis of Autoimmune Disease. Small. 2021 Jun;17(25):e2101655.
  59. Zeng Q, Gao J, Zhang X, Liu A, Wang Z, Wang Z, Chi X, Shi Q, Wang Y, Yang F, Liu Y, Li ZG. Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case-control study based on 450 patients. Sci Rep. 2021 May 17;11(1):10397.
  60. Jin J, Li J, Gan Y, Liu J, Zhao X, Chen J, Zhang R, Zhong Y, Chen X, Wu L, Xiang X, Zhou Y, He J, Guo J, Liu X, Li Z. Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study. Sci Rep. 2021 Mar 11;11(1):5681.
  61. Liu H, Zou Y, Chen C, Tang Y, Guo J. Current Understanding of Circular RNAs in Systemic Lupus Erythematosus. Front Immunol. 2021 Feb 25;12:628872.
  62. Chen J, Sun F, Bao H, Liang L, Zhan M, Yao H, He J, Liu Y. Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjögren's Syndrome. Front Immunol. 2021 Jun 23;12:670642.
  63. Liang Y, Xian Z, Fu D, Liu S, Yao Y, Jin Y, Gao C, Shen L, Shi G, He J. IL-14α as a Putative Biomarker for Stratification of Dry Eye in Primary Sjögren's Syndrome. Front Immunol. 2021 May 3;12:673658.
  64. Liang K, He J, Wei Y, Zeng Q, Gong D, Qin J, Ding H, Chen Z, Zhou P, Niu P, Chen Q, Ding C, Lu L, Chen XX, Li Z, Shen N, Yu D, Deng J. Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus. Clin Transl Immunology. 2021 Jun 1;10(6):e1293. 
  65. Liu Y, Zhu L, Wang Z, Zeng Q, Yang F, Gao J, Wang Z, Wang K, Ren L, Zhang Y, Zhang S, Wang Y, Shen D, Xia C, Yu G, Li Z. Clinical features of IgG4-related retroperitoneal fibrosis among 407 patients with IgG4-related disease: a retrospective study. Rheumatology (Oxford). 2021 Feb 1;60(2):767-772.
  66. Zhou X, Liu Y, Jin Y, Wang Y, Miao M, Chen J, Cheng Y, Liu Y, He J, Li Z. Immune responses after influenza vaccination in patients of primary Sjögren's syndrome. Rheumatology (Oxford). 2021 Jan 5;60(1):224-230.
  67. Chen S, Guo C, Wang R, Feng Z, Liu Z, Wu L, Zhao D, Zheng S, Chen F, Zhang D, Xu J, Zhu J, Chen X, Li Z, Wise CM, Li J, Wang XY. Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2021 May 14;60(5):2409-2420.
  68. Wang Y, Xiao J, Duan Y, Miao M, Huang B, Chen J, Cheng G, Zhou X, Jin Y, He J, Li Z, So KF. Lycium barbarum Polysaccharide Ameliorates Sjögren's Syndrome in a Murine Model. Mol Nutr Food Res. 2021 Jun;65(11):e2001118.
  69. Miao M, Xiao X, Tian J, Zhufeng Y, Feng R, Zhang R, Chen J, Zhang X, Huang B, Jin Y, Sun X, He J, Li Z. Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study. Arthritis Res Ther. 2021 Jun 11;23(1):167.
  70. Zhao Z, Mou D, Wang Z, Zeng Q, Wang Z, Xue J, Ren L, Liu Y, Su Y. Clinical features and relapse risks of IgG4-related ophthalmic disease: a single-center experience in China. Arthritis Res Ther. 2021 Mar 31;23(1):98.
  71. Liu Y, Yang F, Chi X, Zhang Y, Fu J, Bian W, Shen D, Li Z. Needle biopsy compared with surgical biopsy: pitfalls of small biopsy in histologial diagnosis of IgG4-related disease. Arthritis Res Ther. 2021 Feb 10;23(1):54.
  72. Li X, Ye H. bFGF could be a biomarker of malignancy in RS3PE syndrome: an ambispective single-center cohort analysis of 51 patients. Arthritis Res Ther. 2021 Oct 15;23(1):261.
  73. Fu W, Liu Y, Liu F, Liu C, Li J, Niu J, Han P, Xu D, Hou J, Ma Y, Feng J, Li Z, Mu R, Yang G. A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis. Front Immunol. 2021 Mar 25;12:656090.
  74. Yang Y, Xu J, Xu J, Li X, Hu J, Li X, Zhang X, He D, Bao C, Li Z, Wang G, Zerbini CAF, Spindler AJ, Kannowski CL, Wu H, Ji F, Zhan L, Liu M, Li Z. Patient-reported outcomes from a randomized, double-blind, placebo controlled, phase III study of baricitinib versus placebo in patients with moderately to severely active rheumatoid arthritis and an inadequate response to methotrexate therapy: results from the RA-BALANCE study. Ther Adv Musculoskelet Dis. 2021 Apr 20;13:1759720X211006964.
  75. Hu F, Tang Y, Wang P, Bai M, Li X, Song J, Shi L, Sun X, Jin M, Li Z, Li X. Endoplasmic reticulum stress perpetuated toll-like receptor signalling-mediated inflammation in rheumatoid arthritis via X-box-binding protein-1. Clin Exp Rheumatol. 2021 Jul-Aug;39(4):859-867.
  76. Miao M, Li Y, Xu D, Zhang R, He J, Sun X, Li Z. Therapeutic responses and predictors of low-dose interleukin-2 in systemic lupus erythematosus. Clin Exp Rheumatol. 2021 May 5.
  77. Bonfá E, Gossec L, Isenberg DA, Li Z, Raychaudhuri S. How covid-19 is changing rheumatology clinical practice. Nat Rev Rheumatol. 2020 Nov 2:1-5.
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